University of Mary Washington Research and Creativity Day 2023

Tag: Victoria Ashton

  • The Effects of Injury on PDGFRβ Expression in a DM1 Context

    By Victoria Ashton Faculty Mentor: Dr. Ginny Morriss Abstract Myotonic Dystrophy Type 1 (DM1) is a condition that causes severe weakening and wasting of muscles, caused by an expansion of CTG repeats in the DMPK gene. Previous studies have shown that activation of the protein platelet-derived growth factor receptor beta (PDGFRβ) is deregulated in DM1.…

  • Investigating the Role of pvr in Drosophila melanogaster DM1-Related Muscle-Wasting

    By Victoria Ashton, Delaney Baratka, John Conrad Tan Faculty Mentor: Dr. Ginny Morriss Abstract DM1 is a progressive and multi-systemic muscle-wasting disorder caused by an expansion of CTG repeats in the 3’ UTR region in the DMPK gene. Though the mechanism of how DM1 works is still unknown, research has indicated that PDGFRβ pathway signaling…

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